Product Details

Maintaining your SAM-e levels plays an important role in supporting a healthy mood. SAM-e is a naturally occurring molecule made in the cells of our body. However, SAM-e can run low due to various factors such as diet and aging. Nature Made SAM-e Complete may help to replenish your SAM-e levels and restore your healthy mood when taken daily.†

Nature Made SAM-e also helps support joint comfort.† SAM-e provides a source of sulfur, which is a critical component to joint tissue.

  • #1 Best Selling Brand of SAM-e supplement*
  • Clinically studied to support a healthy mood†
  • Help restore a healthy mood in as little as 7 to 14 days when taken daily†
  • 100% money back guarantee**

Nature Made SAM-e Complete is made to Nature Made’s guaranteed purity and potency standards.

  • No Artificial Flavors
  • No Preservatives
  • No Yeast
  • Gluten Free


SAM-e Complete 400 mg Tablets

SKU: 125
  • When to Take:

    Start with 2 tablets per day. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. Clinical studies indicate that benefits are most likely evident after 7-14 days of supplementation. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To help determine the proper level of supplementation that works you, gradually increase the number of tablets (maximum 1600 mg/day) and consult with your doctor until benefits are achieved.




    SAM-e should be avoided when taking:

    • St. John’s Wort and MAO Inhibitors, like Marplan, Nardil, Parnate, Manerix

    SAM-e should be used with caution and only under a doctor’s supervision when combined with:

    • Other drugs that increase neurotransmitters in the body such as Selective Serotonin Reuptake Inhibitors (SSRIs)

    Caution: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide should not take this or any other product containing SAM-e except under a doctor's supervision. If you are pregnant or nursing, or taking prescription antidepressant medications, consult your doctor before using this product.


    Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product.  Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

    • Diminished drug effectiveness
    • Reduced supplement effectiveness
    • Impaired drug and/or supplement absorption


  • For 40 years, we have been obsessed with quality at Nature Made®. From ingredient sourcing, to industry-leading manufacturing practices, to our third-party verification approach, we believe it is our responsibility to lead in delivering quality products and a quality consumer experience. For more information, click here

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